Article
Integrin-mediated adhesion regulates membrane order.
The Journal of cell biology - 28 Aug 2006
Gaus Katharina, Le Lay Soazig, Balasubramanian Nagaraj, Schwartz Martin A
Abstract excerpt
The properties of cholesterol-dependent domains (lipid rafts) in cell membranes have been controversial. Because integrin-mediated cell adhesion and caveolin both regulate trafficking of raft components, we investigated the effects of adhesion and caveolin on membrane order. The fluorescent probe Laurdan and two-photon microscopy revealed that focal adhesions are highly ordered; in fact, they are more ordered...
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