Article
Impact of platinum on the whole mitochondrial genome of ovarian carcinomas both in vivo and in vitro.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Apr 2009
Shi Honghui, Pan Lingya, Song Tian
Abstract excerpt
OBJECTIVES: To investigate somatic mitochondrial DNA mutation in primary and recurrent ovarian carcinoma tissues as well as that in drug-resistant cell lines to illuminate the impact of chemotherapeutic drugs on mitochondrial DNA (mtDNA). METHODS: Complete mtDNA genomes of 20 pairs of ovarian car...
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