Article
Structure of the gene of tum- transplantation antigen P198: a point mutation generates a new antigenic peptide.
The Journal of experimental medicine - 1 Jul 1990
Sibille C, Chomez P, Wildmann C, Van Pel A, De Plaen E, Maryanski J L, de Bergeyck V, Boon T
Abstract excerpt
Mutagen treatment of mouse tumor cell line P815 produces tum- variants that are rejected by syngeneic mice because they express new transplantation antigens. These tum- antigens are recognized by cytotoxic T lymphocytes (CTL) but induce no detectable antibody response. By transfecting P815 cell line P1.HTR with DNA of tum- variant P198, we obtained transfectants expressing tum- antigen P198 that could be...
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