Article
Structure of the gene of tum- transplantation antigen P35B: presence of a point mutation in the antigenic allele.
The EMBO journal - 1 Apr 1990
Szikora J P, Van Pel A, Brichard V, André M, Van Baren N, Henry P, De Plaen E, Boon T
Abstract excerpt
Mutagen treatment of P815 tumour cells produces tum- variants that are rejected by syngeneic mice because they express new transplantation antigens. These 'tum-' antigens elicit a cytolytic T lymphocyte (CTL) response but no detectable antibody response. The DNA of tum- variant P35 was transfected into P815 cell line P1.HTR. Transfectants expressing tum- antigen P35B were identified on the basis of their ability...
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