Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The immunoprotective MHC II epitope of a chemically induced tumor harbors a unique mutation in a ribosomal protein.

Proceedings of the National Academy of Sciences of the United States of America - 27 Mar 2001

Matsutake T, Srivastava P K

Abstract excerpt

CD4(+) T lymphocyte clones, generated from mice immunized with the methylcholanthrene-induced fibrosarcoma Meth A (H-2(d)), are restricted by I-E(d) and recognize a unique antigen on Meth A. The antigen has been purified and characterized as the ribosomal protein L11. The antigenic epitope is contained within the sequence EYELRKHNFSDTG and is generated by substitution of Asn by His (italic) caused by a single...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Neoplasm
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epitopes

Share to Fibrosarcoma

Share to Histocompatibility Antigens

Share to Histocompatibility Antigens Class II

Share to Ribosomal Proteins

Share to Sequence Homology, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 11274422
DOI: 10.1073/pnas.071523398
PMCID: PMC31167

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The immunoprotective MHC II epitope of a chemically induced tumor harbors a unique mutation in a ribosomal protein.PMID 11274422Read ↗

Point mutation in essential genes with loss or mutation of the second allele: relevance to the retention of tumor-specific antigens.Semantic proximity Read ↗

Reversion analysis reveals the in vivo immunogenicity of a poorly MHC I-binding cancer neoepitope.Semantic proximity Read ↗

The Immunodominant Antigen of an Ultraviolet-induced Regressor Tumor Is Generated by a Somatic Point Mutation in the DEAD Box Helicase p68Semantic proximity Read ↗

Subunit peptide cancer vaccines targeting activating mutations of the p21 ras proto-oncogene.Semantic proximity Read ↗

Induction in transgenic mice of HLA-A2.1-restricted cytotoxic T cells specific for a peptide sequence from a mutated p21ras protein.Semantic proximity Read ↗

Identification of H-2Kb-, Db- and Dd-binding peptides derived from amino acid sequences of polyoma virus T antigens.Semantic proximity Read ↗

Structure of the gene of tum- transplantation antigen P198: a point mutation generates a new antigenic peptide.Semantic proximity Read ↗

Invariant chain alters the malignant phenotype of MHC class II+ tumor cells.Semantic proximity Read ↗

Reductive methylation and mutation of an anthrax toxin fusion protein modulates its stability and cytotoxicity.Semantic proximity Read ↗

T cell recognition of transforming proteins encoded by mutated ras proto-oncogenes.Semantic proximity Read ↗

Heterogeneity of MHC-class-I antigens in clones of methylcholanthrene-induced tumors. Implications for local growth and metastasis.Semantic proximity Read ↗

Mutation in the immunodominant epitope of the HPV16 E7 oncoprotein as a mechanism of tumor escape.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.