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Article

Evolution of multi-drug resistant hepatitis B virus during sequential therapy.

Hepatology (Baltimore, Md.) - 1 Sept 2006

Yim Hyung Joon, Hussain Munira, Liu Ying, Wong Stephen N, Fung Scott K, Lok Anna S F

Abstract excerpt

Multi-drug resistant hepatitis B virus (HBV) has been reported in hepatitis B patients who received sequential antiviral therapy. In vitro studies showed that HBV constructs with mutations resistant to lamivudine and adefovir have marked reduction in sensitivity to combination of lamivudine and adefovir, whereas constructs with mutations resistant to either drug remain sensitive to the other drug. We conducted...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16941700
DOI: 10.1002/hep.21290

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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