Article
Characterization of hepatitis virus B isolated from a multi-drug refractory patient.
Virus research - 1 Jan 2011
Wei Chen, Chong Yu-Tian, Wen Ji-Zhi, Li Yong-Wei, Li Gang
Abstract excerpt
Prolonged treatment of chronic hepatitis B (CHB) with nucleoside analogues (NAs) almost invariably engenders viral resistance, and sequential NAs monotherapy can promote multi-drug resistance. This study aimed to investigate the molecular characteristics and the mutation profile of multi-drug resistant hepatitis B virus (HBV). The complete genome of HBV isolated from a multi-drug refractory patient was amplified...
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