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Article

Adefovir and lamivudine combination therapy in patients with entecavir-resistant chronic hepatitis B: antiviral responses and evolution of mutations.

Intervirology - 1 Jan 2014

Yim Hyung Joon, Lee Hyun Jung, Suh Sang Jun, Seo Yeon Seok, Kim Chang Wook, Lee Chang Don, Park Sang Hoon, Lee Myung Seok, Park Choong Kee, Chae Hee Bok, Kim Moon Young, Baik Soon Koo, Kim Yun Soo, Kim Ju Hyun, Lee Jung Il, Lee Jin Woo, Hong Sun Pyo, Um Soon Ho

Abstract excerpt

OBJECTIVE: This study was designed to prospectively evaluate the antiviral responses and evolution of resistance mutations during adefovir (ADV) plus lamivudine (LMV) therapy in patients with entecavir (ETV)-resistant hepatitis B virus (HBV) infection. METHODS: Twenty chronic hepatitis B (CHB) patients who had been receiving ETV for more than 6 months and developed virologic breakthrough due to ETV resistance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24993731
DOI: 10.1159/000360399

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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