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Article

A translational study of resistance emergence using sequential direct-acting antiviral agents for hepatitis C using ultra-deep sequencing.

The American journal of gastroenterology - 1 Sept 2013

Abe Hiromi, Hayes C Nelson, Hiraga Nobuhiko, Imamura Michio, Tsuge Masataka, Miki Daiki, Takahashi Shoichi, Ochi Hidenori, Chayama Kazuaki

Abstract excerpt

OBJECTIVES: Direct-acting antiviral agents (DAAs) against hepatitis C virus (HCV) have recently been developed and are ultimately hoped to replace interferon-based therapy. However, DAA monotherapy results in rapid emergence of resistant strains and DAAs must be used in combinations that present a high genetic barrier to resistance, although viral kinetics of multidrug-resistant strains remain poorly...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23896953
DOI: 10.1038/ajg.2013.205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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