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Article

Clonal evolution of hepatitis B virus polymerase gene mutations during lamivudine-adefovir combination treatment.

World journal of gastroenterology - 28 Nov 2012

Ko Soon Young, Kim Byung Kook, Kwon So Young, Kim Kyun-Hwan, Kim Jeong Han, Choe Won Hyeok, Lee Chang Hong

Abstract excerpt

AIM: To identify hepatitis B virus polymerase gene mutations during antiviral therapy using lamivudine-adefovir sequential monotherapy followed by lamivudine-adefovir combination therapy. METHODS: The patient cohort included four adult chronic hepatitis B patients who had undergone sequential monotherapy, first with lamivudine (LMV) and then, after developing viral breakthrough, with adefovir (ADV) therapy. All...

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Identifiers

PMID: 23197889
DOI: 10.3748/wjg.v18.i44.6437
PMCID: PMC3508638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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