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Article

Ca2+/recoverin dependent regulation of phosphorylation of the rhodopsin mutant R135L associated with retinitis pigmentosa.

Biochemical and biophysical research communications - 13 Oct 2006

Senin Ivan I, Bosch Laia, Ramon Eva, Zernii Evgeni Yu, Manyosa Joan, Philippov Pavel P, Garriga Pere

Abstract excerpt

No single molecular mechanism accounts for the effect of mutations in rhodopsin associated with retinitis pigmentosa. Here we report on the specific effect of a Ca2+/recoverin upon phosphorylation of the autosomal dominant retinitis pigmentosa R135L rhodopsin mutant. This mutant shows specific features like impaired G-protein signaling but enhanced phosphorylation in the shut-off process. We now report that R135L...

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PMID: 16934219
DOI: 10.1016/j.bbrc.2006.08.048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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