Article
Alterations in the photoactivation pathway of rhodopsin mutants associated with retinitis pigmentosa.
The FEBS journal - 1 May 2011
Bosch-Presegué Laia, Ramon Eva, Toledo Darwin, Cordomí Arnau, Garriga Pere
Abstract excerpt
The visual photoreceptor rhodopsin undergoes a series of conformational changes upon light activation, eventually leading to the active metarhodopsin II conformation, which is able to bind and activate the G-protein, transducin. We have previously shown that mutant rhodopsins G51V and G89D, associated with retinitis pigmentosa, present photobleaching patterns characterized by the formation of altered...
Topics
- Humans
- Light
- Models, Molecular
- Mutation
- Protein Conformation
- Retinitis Pigmentosa
- Rhodopsin
- Spectrophotometry, Ultraviolet