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Article

Structure and membrane-targeting mechanism of retinal Ca2+-binding proteins, recoverin and GCAP-2.

Advances in experimental medicine and biology - 1 Jan 2002

Ames James B, Ikura Mitsuhiko

Abstract excerpt

Recoverin and the guanylate cyclase activating proteins (GCAPs) are calcium-sensing proteins in retinal rod and cone cells that belong to the EF-hand superfamily and serve as important calcium sensors in vision. Recoverin and the OCAP proteins are myristoylated at their amino-terminus and are targeted to retinal disc membranes by a myristoyl switch. Here, we present the three-dimensional, atomic-resolution...

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Identifiers

PMID: 12596931
DOI: 10.1007/978-1-4615-0121-3_20

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structure and membrane-targeting mechanism of retinal Ca2+-binding proteins, recoverin and GCAP-2.PMID 12596931Read ↗

Structure and calcium-binding studies of a recoverin mutant (E85Q) in an allosteric intermediate state.Semantic proximity Read ↗

Functional restoration of the Ca2+-myristoyl switch in a recoverin mutant.Semantic proximity Read ↗

A highly conserved cysteine of neuronal calcium-sensing proteins controls cooperative binding of Ca2+ to recoverin.Semantic proximity Read ↗

Calcium Sensing by Recoverin: Effect of Protein Conformation on Ion Affinity.Semantic proximity Read ↗

Effects of mutations in the calcium-binding sites of recoverin on its calcium affinity: evidence for successive filling of the calcium binding sites.Semantic proximity Read ↗

Molecular properties of human guanylate cyclase-activating protein 2 (GCAP2) and its retinal dystrophy-associated variant G157R.Semantic proximity Read ↗

Structural and functional investigation of RD3-GCAP1 interaction in retinal photoreceptors under normal and disease conditions.Semantic proximity Read ↗

Recoverin binds exclusively to an amphipathic peptide at the N terminus of rhodopsin kinase, inhibiting rhodopsin phosphorylation without affecting catalytic activity of the kinase.Semantic proximity Read ↗

Calcium binding, structural stability and guanylate cyclase activation in GCAP1 variants associated with human cone dystrophy.Semantic proximity Read ↗

Recoverin is a zinc-binding protein.Semantic proximity Read ↗

Site-directed and natural mutations in studying functional domains in guanylyl cyclase activating proteins (GCAPs).Semantic proximity Read ↗

Obtaining and characterization of EF-hand mutants of recoverin.Semantic proximity Read ↗

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