Article
An association between glutathione S-transferase P1 gene polymorphism and younger age at onset of lung carcinoma.
Cancer - 1 Oct 2006
Miller David P, Asomaning Kofi, Liu Geoffrey, Wain John C, Lynch Thomas J, Neuberg Donna, Su Li, Christiani David C
Abstract excerpt
BACKGROUND: Among the genes that encode the glutathione S-transferase (GST) superfamily of Phase 2 metabolizing enzymes, GSTP1 has the highest expression in the lung. The polymorphic GSTP1 gene encodes glutathione S-transferase pi, which is an enzyme that detoxifies cigarette carcinogens, such as benzo-[a]-pyrene. The variant GSTP1 GG genotype is associated with lower enzymatic activity and higher DNA adduct...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.