Article
Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: a HuGE-GSEC review.
American journal of epidemiology - 1 Apr 2009
Cote Michele L, Chen Wei, Smith Daryn W, Benhamou Simone, Bouchardy Christine, Butkiewicz Dorota, Fong Kwun M, Gené Manuel, Hirvonen Ari, Kiyohara Chikako, Larsen Jill E, Lin Pinpin, Raaschou-Nielsen Ole, Povey Andrew C, Reszka Edyta, Risch Angela, Schneider Joachim, Schwartz Ann G, Sorensen Mette, To-Figueras Jordi, Tokudome Shinkan, Pu Yuepu, Yang Ping, Wenzlaff Angela S, Wikman Harriet, Taioli Emanuela
Abstract excerpt
Lung cancer is the most common cancer worldwide. Polymorphisms in genes associated with carcinogen metabolism may modulate risk of disease. Glutathione S-transferase pi (GSTP1) detoxifies polycyclic aromatic hydrocarbons found in cigarette smoke and is the most highly expressed glutathione S-transferase in lung tissue. A polymorphism in the GSTP1 gene, an A-to-G transition in exon 5 (Ile105Val, 313A --> 313G),...
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