Article
Glutathione S-transferase M1, T1 and P1 polymorphisms: susceptibility and outcome in lung cancer patients.
Journal of experimental therapeutics & oncology - 1 Jan 2008
Sreeja Leelakumari, Syamala Vani, Hariharan Sreedharan, Syamala Volga S, Raveendran Praveenkumar B, Sivanandan C D, Madhavan Jayaprakash, Ankathil Ravindran
Abstract excerpt
The glutathione S-transferases (GSTs) are a superfamily of genes whose products are phase II enzymes, catalyzing the conjugation of reactive intermediates to soluble glutathione. Some of the GSTs are polymorphic and may play a role in lung cancer susceptibility. We investigated whether genetic polymorphisms of GSTM1, GSTP1 and GSTT1 genes modulated lung cancer risk and affect survival among lung cancer patients....
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