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Article

Characterization of the substrate specificity of PhlD, a type III polyketide synthase from Pseudomonas fluorescens.

The Journal of biological chemistry - 20 Oct 2006

Zha Wenjuan, Rubin-Pitel Sheryl B, Zhao Huimin

Abstract excerpt

PhlD, a type III polyketide synthase from Pseudomonas fluorescens, catalyzes the synthesis of phloroglucinol from three molecules of malonyl-CoA. Kinetic analysis by direct measurement of the appearance of the CoASH product (k(cat) = 24 +/- 4 min(-1) and Km = 13 +/- 1 microM) gave a k(cat) value more than an order of magnitude higher than that of any other known type III polyketide synthase. PhlD exhibits broad...

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Identifiers

PMID: 16931521
DOI: 10.1074/jbc.M606500200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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