Article
Polymorphisms in the TNFA gene and the risk of inhibitor development in patients with hemophilia A.
Blood - 1 Dec 2006
Astermark Jan, Oldenburg Johannes, Carlson Joyce, Pavlova Anna, Kavakli Kaan, Berntorp Erik, Lefvert Ann-Kari
Abstract excerpt
The HLA class I/II alleles and the tumor necrosis factor alpha (TNFA) locus are closely linked in the MHC complex. We have characterized the causative factor VIII mutation, HLA alleles as well as 4 polymorphisms (-827C>T, -308G>A, -238A>G, and 670A>G) in the TNFA gene in 164 patients (124 severe, 26 moderate, and 14 mild) in 78 families with hemophilia A enrolled in the Malmö International Brother Study (MIBS)....
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