Article
Targeted disruption of the synovial sarcoma-associated SS18 gene causes early embryonic lethality and affects PPARBP expression.
Human molecular genetics - 1 Oct 2006
de Bruijn D R H, Peters W J M, Chuva de Sousa Lopes S M, van Dijk A H A, Willemse M P, Pfundt R, de Boer P, Geurts van Kessel A
Abstract excerpt
The synovial sarcoma-associated protein SS18 (also known as SYT or SSXT) is thought to act as a transcriptional co-activator. This activity appears to be mediated through the SWI/SNF proteins BRG1 and INI1 and the histone acetyl transferase p300. Here, we report that disruption of the mouse Ss18 gene results in a recessive embryonic lethal phenotype, due to placental failure caused by impairment of placental...
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