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Article

Synovial Sarcoma: Recent Discoveries as a Roadmap to New Avenues for Therapy

23 Jan 2015

Abstract excerpt

UNLABELLED: Oncogenesis in synovial sarcoma is driven by the chromosomal translocation t(X,18; p11,q11), which generates an in-frame fusion of the SWI/SNF subunit SS18 to the C-terminal repression domains of SSX1 or SSX2. Proteomic studies have identified an integral role of SS18-SSX in the SWI/SNF complex, and provide new evidence for mistargeting of polycomb repression in synovial sarcoma. Two recent in vivo...

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PMID: 25614489
DOI: 10.1158/2159-8290.cd-14-1246

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