Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Synovial Sarcoma–Associated SS18-SSX2 Fusion Protein Induces Epigenetic Gene (De)Regulation

1 Oct 2006

Abstract excerpt

Fusion of the SS18 and either one of the SSX genes is a hallmark of human synovial sarcoma. The SS18 and SSX genes encode nuclear proteins that exhibit opposite transcriptional activities. The SS18 protein functions as a transcriptional coactivator and is associated with the SWI/SNF complex, whereas the SSX proteins function as transcriptional corepressors and are associated with the polycomb complex. The domains...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Genomics and Chromatin Dynamics
Share to Sarcoma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17018603
DOI: 10.1158/0008-5472.can-05-3726

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Synovial Sarcoma–Associated SS18-SSX2 Fusion Protein Induces Epigenetic Gene (De)RegulationPMID 17018603Read ↗

The (Epi)genetics of human synovial sarcomaSemantic proximity Read ↗

Histone Deacetylase Inhibitors Reverse SS18-SSX–Mediated Polycomb Silencing of the Tumor Suppressor <i>Early Growth Response 1</i> in Synovial SarcomaSemantic proximity Read ↗

Synovial Sarcoma: Recent Discoveries as a Roadmap to New Avenues for TherapySemantic proximity Read ↗

Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stabilitySemantic proximity Read ↗

SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic ModifierSemantic proximity Read ↗

Fusions of the SYT and SSX genes in synovial sarcoma.Semantic proximity Read ↗

The clinical implication of SS18 -SSX fusion gene in synovial sarcomaSemantic proximity Read ↗

Synovial Sarcoma Chromatin Dynamics Reveal a Continuum in SS18:SSX ReprogramingSemantic proximity Read ↗

Molecular and epigenetic oncogenesis in synovial sarcoma: implications for cancer biology, diagnosis and treatmentSemantic proximity Read ↗

Gene expression profiles relate to SS18/SSX fusion type in synovial sarcomaSemantic proximity Read ↗

The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis.Semantic proximity Read ↗

Molecular Profiling Defines Three Subtypes of Synovial SarcomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.