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Article

Fusions of the SYT and SSX genes in synovial sarcoma.

Oncogene - 10 Sept 2001

Ladanyi M

Abstract excerpt

Synovial sarcomas are high grade spindle cell tumors that are divided into two major histologic subtypes, biphasic and monophasic, according to the respective presence or absence of a well-developed glandular epithelial component. They contain in essentially all cases a t(X;18) representing the fusion of SYT (at 18q11) with either SSX1 or SSX2 (both at Xp11). Neither SYT, nor the SSX proteins contain DNA-binding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11607825
DOI: 10.1038/sj.onc.1204601

Genes

SSX1
SSX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Fusions of the SYT and SSX genes in synovial sarcoma.PMID 11607825Read ↗

Molecular mechanisms underlying human synovial sarcoma developmentSemantic proximity Read ↗

<i>SYT–SSX</i> Gene Fusion as a Determinant of Morphology and Prognosis in Synovial SarcomaSemantic proximity Read ↗

SYT-SSX1 and SYT-SSX2 Interfere with Repression of E-Cadherin by Snail and Slug: A Potential Mechanism for Aberrant Mesenchymal to Epithelial Transition in Human Synovial SarcomaSemantic proximity Read ↗

The Synovial Sarcoma–Associated SS18-SSX2 Fusion Protein Induces Epigenetic Gene (De)RegulationSemantic proximity Read ↗

The (Epi)genetics of human synovial sarcomaSemantic proximity Read ↗

Synovial Sarcoma: Recent Discoveries as a Roadmap to New Avenues for TherapySemantic proximity Read ↗

Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel‐associated box in human synovial sarcoma.Semantic proximity Read ↗

Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stabilitySemantic proximity Read ↗

Identification of a novel spliced variant of the SYT gene expressed in normal tissues and in synovial sarcoma.Semantic proximity Read ↗

Synovial Sarcoma Preclinical Modeling: Integrating Transgenic Mouse Models and Patient-Derived Models for Translational ResearchSemantic proximity Read ↗

Synovial Sarcoma Chromatin Dynamics Reveal a Continuum in SS18:SSX ReprogramingSemantic proximity Read ↗

Clinical impact of molecular and cytogenetic findings in synovial sarcomaSemantic proximity Read ↗

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