Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Synovial Sarcoma: From Genetics to Genetic-based Animal Modeling

17 Jun 2008

Abstract excerpt

Synovial sarcomas are highly aggressive mesenchymal cancers that show modest response to conventional cytotoxic chemotherapy, suggesting a definite need for improved biotargeted agents. Progress has been hampered by the lack of insight into pathogenesis of this deadly disease. The presence of a specific diagnostic t(X;18) translocation leading to expression of the unique SYT-SSX fusion protein in effectively all...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Lymphoma Diagnosis and Treatment
Share to Sarcoma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18563504
DOI: 10.1007/s11999-008-0340-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Synovial Sarcoma: From Genetics to Genetic-based Animal ModelingPMID 18563504Read ↗

Synovial Sarcoma Preclinical Modeling: Integrating Transgenic Mouse Models and Patient-Derived Models for Translational ResearchSemantic proximity Read ↗

A CreER-Based Random Induction Strategy for Modeling Translocation-Associated Sarcomas in MiceSemantic proximity Read ↗

The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis.Semantic proximity Read ↗

Molecular mechanisms underlying human synovial sarcoma developmentSemantic proximity Read ↗

Targeting the Wnt Pathway in Synovial Sarcoma ModelsSemantic proximity Read ↗

β-catenin stabilization enhancesSS18-SSX2-driven synovial sarcomagenesis and blocks the mesenchymal to epithelial transitionSemantic proximity Read ↗

Tissue microarray profiling of primary and xenotransplanted synovial sarcomas demonstrates the immunophenotypic similarities existing between SYT-SSX fusion gene confirmed, biphasic, and monophasic fibrous variants.Semantic proximity Read ↗

IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1Semantic proximity Read ↗

Cell-of-origin epigenome underlies SS18::SSX-mediated transformationSemantic proximity Read ↗

Genetic and Molecular Heterogeneity of Synovial Sarcoma and Associated Challenges in TherapySemantic proximity Read ↗

<i>SYT–SSX</i> Gene Fusion as a Determinant of Morphology and Prognosis in Synovial SarcomaSemantic proximity Read ↗

Innovative Breakthroughs for the Treatment of Advanced and Metastatic Synovial SarcomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.