Article
The p22phox C242T gene polymorphism is associated with a reduced risk of angiographically verified coronary artery disease in a high-risk Finnish Caucasian population. The Finnish Cardiovascular Study.
American heart journal - 1 Sept 2006
Fan Meng, Kähönen Mika, Rontu Riikka, Lehtinen Rami, Viik Jari, Niemi Mari, Nieminen Tuomo, Niemelä Kari, Pörsti Ilkka, Kööbi Tiit, Turjanmaa Väinö, Lehtimäki Terho
Abstract excerpt
BACKGROUND: Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is a major source of the superoxide anion, which may play an important role in the development of atherosclerosis and coronary artery disease (CAD). The p22phox, a component of the NADPH oxidase, is essential for the activation of this enzyme, and intensive expression of the p22phox has been reported in human atherosclerotic arteries....
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