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Article

RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity.

Cellular signalling - 1 Jan 2007

Onishi Ichiro, Lin Paulo J C, Diering Graham H, Williams Warren P, Numata Masayuki

Abstract excerpt

Na+/H+ exchanger isoform 5 (NHE5) is a brain-enriched NHE that may play important roles in ion homeostasis and cell-volume regulation. However, the regulation mechanism of NHE5 has not been fully elucidated. Here, we show that Receptor for Activated C-kinase 1 (RACK1) directly binds to NHE5 and positively regulates the transporter function. NHE5 co-localized with RACK1 as well as beta1 integrin, paxillin and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16920332
DOI: 10.1016/j.cellsig.2006.06.011

Genes

RACK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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