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Article

Integrin α5 Suppresses the Phosphorylation of Epidermal Growth Factor Receptor and Its Cellular Signaling of Cell Proliferation via N-Glycosylation.

The Journal of biological chemistry - 4 Dec 2015

Hang Qinglei, Isaji Tomoya, Hou Sicong, Im Sanghun, Fukuda Tomohiko, Gu Jianguo

Abstract excerpt

Integrin α5β1-mediated cell adhesion regulates a multitude of cellular responses, including cell proliferation, survival, and cross-talk between different cellular signaling pathways. Integrin α5β1 is known to convey permissive signals enabling anchorage-dependent receptor tyrosine kinase signaling. However, the effects of integrin α5β1 on cell proliferation are controversial, and the molecular mechanisms...

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Identifiers

PMID: 26483551
DOI: 10.1074/jbc.M115.682229
PMCID: PMC4705939

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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