Article
CD98 modulates integrin beta1 function in polarized epithelial cells.
Journal of cell science - 1 Mar 2005
Cai Songmin, Bulus Nada, Fonseca-Siesser Priscila M, Chen Dong, Hanks Steven K, Pozzi Ambra, Zent Roy
Abstract excerpt
The type II transmembrane protein CD98, best known as the heavy chain of the heterodimeric amino acid transporters (HAT), is required for the surface expression and basolateral localization of this transporter complex in polarized epithelial cells. CD98 also interacts with beta1 integrins resulting in an increase in their affinity for ligand. In this study we explored the role of the transmembrane and cytoplasmic...
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