Article
A promoter polymorphism in the interferon alpha-2 gene is associated with the clinical presentation of hepatitis B.
Mutation research - 10 Oct 2006
Song Le H, Toan Nguyen L, Xuan Nguyen T, Uhlemann Anne-Catrin, Boldt Angelica B W, Duy Dinh N, Binh Vu Q, Kremsner Peter G, Kun Jürgen F J
Abstract excerpt
Cytokine gene polymorphisms influence the severity of infectious diseases of viral and parasitic origin. Interferon alpha (IFN-alpha) is known to be involved in the defence against hepatitis B. The promoter of the IFN-alpha-2 gene was investigated for mutations in 344 hepatitis B virus (HBV)-infected Vietnamese patients and 293 uninfected Vietnamese. We found a deletion in the promoter, which was present...
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