Article
A globally occurring indel polymorphism in the promoter of the IFNA2 gene is not associated with severity of malaria but with the positivity rate of HCV.
BMC genetics - 3 Dec 2008
Tena-Tomás Cristina, de Messias-Reason Iara, Song Le H, Tomiuk Jürgen, Kemsner Peter G, Kun Jürgen F J
Abstract excerpt
BACKGROUND: Type I Interferons (IFNs) are well known cytokines which exert antiviral activity, antitumor activity and immunomodulatory effects. Single-nucleotide polymorphisms (SNP) and deletions in the gene coding for IFNA2 have been shown to influence the level of expression in vitro. The indel polymorphism -305_-300delAACTTT showed the strongest effect in vitro. To analyse the worldwide distribution of this...
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