Article
Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site.
Structure (London, England : 1993) - 1 Oct 2005
Jauch Ralf, Jäkel Stefan, Netter Catharina, Schreiter Kay, Aicher Babette, Jäckle Herbert, Wahl Markus C
Abstract excerpt
Human mitogen-activated protein kinases (MAPK)-interacting kinases 1 and 2 (Mnk1 and Mnk2) target the translational machinery by phosphorylation of the eukaryotic initiation factor 4E (eIF4E). Here, we present the 2.1 A crystal structure of a nonphosphorylated Mnk2 fragment that encompasses the kinase domain. The results show Mnk-specific features such as a zinc binding motif and an atypical open conformation of...
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