Article
The inflammatory response is influenced by FXIII VAL 34 LEU polymorphism in a human LPS model.
Wiener klinische Wochenschrift - 1 Jan 2009
Kovar Florian M, Marsik Claudia L, Jilma Bernd, Mannhalter Christine, Joukhadar Christian, Wagner Oswald F, Endler Georg
Abstract excerpt
BACKGROUND: In sepsis, activation of coagulation and inhibition of fibrinolysis lead to microvascular thrombosis. The Val34Leu polymorphism affects the function of FXIII by increasing the rate of FXIII activation by thrombin, which results in an increased and faster rate of fibrin stabilization....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.