Article
Interleukin-1 alpha and beta, TNF-alpha and HTTLPR gene variants study on alcohol toxicity and detoxification outcome.
Neuroscience letters - 2 Oct 2006
Serretti Alessandro, Liappas Ioannis, Mandelli Laura, Albani Diego, Forloni Gianluigi, Malitas Petros, Piperi Christina, Zisaki Aikaterini, Tzavellas Elias O, Papadopoulou-Daifoti Zeta, Prato Francesca, Batelli Sara, Pesaresi Marzia, Kalofoutis Anastasios
Abstract excerpt
Genetic factors may influence the liability to treatment outcome and medical complications in alcoholism. In the present study we investigated the IL-1A rs1800587, IL-1B rs3087258, TNF-alpha rs1799724 and the HTTLPR variants in a sample of 64 alcohol dependents and 47 relatives versus a set of clinical parameters and outcome measures. Alcohol dependents had a less favorable clinical profile compared to relatives...
Read the complete abstract on PubMed