Article
New role for serum response factor in postnatal skeletal muscle growth and regeneration via the interleukin 4 and insulin-like growth factor 1 pathways.
Molecular and cellular biology - 1 Sept 2006
Charvet Claude, Houbron Christophe, Parlakian Ara, Giordani Julien, Lahoute Charlotte, Bertrand Anne, Sotiropoulos Athanassia, Renou Laure, Schmitt Alain, Melki Judith, Li Zhenlin, Daegelen Dominique, Tuil David
Abstract excerpt
Serum response factor (SRF) is a crucial transcriptional factor for muscle-specific gene expression. We investigated SRF function in adult skeletal muscles, using mice with a postmitotic myofiber-targeted disruption of the SRF gene. Mutant mice displayed severe skeletal muscle mass reductions due to a postnatal muscle growth defect resulting in highly hypotrophic adult myofibers. SRF-depleted myofibers also...
Topics
- Animals
- Animals, Newborn
- Base Sequence
- Cell Nucleus
- Cell Size
- Gene Expression Regulation
- Insulin-Like Growth Factor I
- Integrases
- Interleukin-4