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Article

Serum response factor is essential for mesoderm formation during mouse embryogenesis.

The EMBO journal - 2 Nov 1998

Arsenian S, Weinhold B, Oelgeschläger M, Rüther U, Nordheim A

Abstract excerpt

The transcription factor serum response factor (SRF), a phylogenetically conserved nuclear protein, mediates the rapid transcriptional response to extracellular stimuli, e.g. growth and differentiation signals. DNA- protein complexes containing SRF or its homologues function as nuclear targets of the Ras/MAPK signalling network, thereby directing gene activities associated with processes as diverse as pheromone...

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Identifiers

PMID: 9799237
DOI: 10.1093/emboj/17.21.6289
PMCID: PMC1170954

Genes

SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Serum response factor is essential for mesoderm formation during mouse embryogenesis.PMID 9799237Read ↗

Serum response factor controls transcriptional network regulating epidermal function and hair follicle morphogenesis.Semantic proximity Read ↗

Restricted inactivation of serum response factor to the cardiovascular system.Semantic proximity Read ↗

Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programsSemantic proximity Read ↗

SRF: a seriously responsible factor in cardiac development and diseaseSemantic proximity Read ↗

Identification of direct serum-response factor gene targets during Me2SO-induced P19 cardiac cell differentiation.Semantic proximity Read ↗

Myocardin-related transcription factor B is required for normal mouse vascular development and smooth muscle gene expression.Semantic proximity Read ↗

Role of the serum response factor in regulating contractile apparatus gene expression and sarcomeric integrity in cardiomyocytes.Semantic proximity Read ↗

Blastocyst formation is blocked in mouse embryos lacking the splicing factor SRp20.Semantic proximity Read ↗

The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development.Semantic proximity Read ↗

Requirement of the mouse I-mfa gene for placental development and skeletal patterning.Semantic proximity Read ↗

Transforming growth factor beta and mouse development.Semantic proximity Read ↗

Early postnatal cardiac changes and premature death in transgenic mice overexpressing a mutant form of serum response factor.Semantic proximity Read ↗

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