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Article

Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart.

Proceedings of the National Academy of Sciences of the United States of America - 18 Nov 2008

Niu Zhiyv, Iyer Dinakar, Conway Simon J, Martin James F, Ivey Kathryn, Srivastava Deepak, Nordheim Alfred, Schwartz Robert J

Abstract excerpt

Our conditional serum response factor (SRF) knockout, Srf (Cko), in the heart-forming region blocked the appearance of rhythmic beating myocytes, one of the earliest cardiac defects caused by the ablation of a cardiac-enriched transcription factor. The appearance of Hand1 and Smyd1, transcription and chromatin remodeling factors; Acta1, Acta2, Myl3, and Myom1, myofibril proteins; and calcium-activated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19004760
DOI: 10.1073/pnas.0805491105
PMCID: PMC2584699

Genes

SRF
BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart.PMID 19004760Read ↗

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