Article
Developmental specificity of recruitment of TBP to the TATA box of the human gamma-globin gene.
Proceedings of the National Academy of Sciences of the United States of America - 16 Apr 2002
Duan Zhi-Jun, Fang Xiangdong, Rohde Alex, Han Hemei, Stamatoyannopoulos George, Li Qiliang
Abstract excerpt
It is unclear whether the core promoter is involved in developmental regulation. To address this question, we mutated the TATA box of the human gamma-globin gene, produced transgenic mice, and examined the effect of the mutation during the course of mouse development. In our test system, the gamma-globin gene is expressed at similar levels in the embryonic and adult erythroid cells. The TATA box mutation...
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