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Molecular Basis for Differential Patterns of Drug Resistance in Influenza N1 and N2 Neuraminidase

7 Nov 2016

Abstract excerpt

Neuraminidase (NA) inhibitors are used for the prevention and treatment of influenza A virus infections. Two subtypes of NA, N1 and N2, predominate in viruses that infect humans, but differential patterns of drug resistance have emerged in each subtype despite highly homologous active sites. To understand the molecular basis for the selection of these drug resistance mutations, structural and dynamic analyses on...

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PMID: 27951676
DOI: 10.1021/acs.jctc.6b00703

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