Article
Mutations within the CD81-binding sites and hypervariable region 2 of the envelope 2 protein: correlation with treatment response in hepatitis C virus-infected patients.
The Journal of infectious diseases - 15 Mar 2003
Hofmann Wolf Peter, Sarrazin Christoph, Kronenberger Bernd, Schönberger Barbara, Bruch Katharina, Zeuzem Stefan
Abstract excerpt
The hepatitis C virus (HCV) envelope 2 (E2) protein interacts with the cellular receptor CD81 in vitro. Within E2, 2 CD81-binding sites were described. E2-CD81 interaction has been shown to modulate B and T cell function. The clinical importance of mutations within the CD81-binding sites and over...
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