Article
Detecting lung cancer in plasma with the use of multiple genetic markers.
International journal of cancer - 1 Jan 2004
Andriani Francesca, Conte Davide, Mastrangelo Tiziana, Leon MariaElena, Ratcliffe Cathy, Roz Luca, Pelosi Giuseppe, Goldstraw Peter, Sozzi Gabriella, Pastorino Ugo
Abstract excerpt
Recent studies have demonstrated the possibility to detect genetic changes in plasma DNA of cancer patients. The goal of this study was to validate a panel of molecular markers for lung cancer detection in plasma DNA. Three markers, p53, FHIT and microsatellite alterations at loci on chromosome 3, were used to detect mutations in tumor and plasma DNA of 64 stage I-III non small cell lung cancer patients. p53...
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