Article
Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib.
Cancer research - 15 Aug 2006
Carey Kendall D, Garton Andrew J, Romero Maria S, Kahler Jennifer, Thomson Stuart, Ross Sarajane, Park Frances, Haley John D, Gibson Neil, Sliwkowski Mark X
Abstract excerpt
We show that two commonly occurring epidermal growth factor receptor (EGFR) somatic mutations, L858R and an in-frame deletion mutant, Del(746-750), exhibit distinct enzymatic properties relative to wild-type EGFR and are differentially sensitive to erlotinib. Kinetic analysis of the purified intr...
Topics
- Cell Division
- Cell Line, Tumor
- Cell Transformation, Neoplastic
- Cloning, Molecular
- ErbB Receptors
- Erlotinib Hydrochloride
- Genetic Vectors
- Humans
- Kinetics
- Mutagenesis
- Mutation
- Protein Kinase Inhibitors
- Quinazolines