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Article

Functional analysis of epidermal growth factor receptor (EGFR) mutations and potential implications for EGFR targeted therapy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2009

Kancha Rama Krishna, von Bubnoff Nikolas, Peschel Christian, Duyster Justus

Abstract excerpt

PURPOSE: Epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) might be predictive for clinical response to EGFR inhibitor treatment. However, retrospective analyses of EGFR mutations in clinical trials have shown inconclusive results and the effect of EGFR sequencing in NSCLC is still controversial. Because the vast majority of EGFR mutations described have not been functionally...

Topics

Amino Acid Sequence
Animals
Antineoplastic Agents
Carcinoma, Non-Small-Cell Lung
Cell Line, Tumor
Cell Membrane
ErbB Receptors
Humans
Inhibitory Concentration 50
Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Medical Oncology

Mice

Molecular Sequence Data

Mutation

NIH 3T3 Cells

Source

Identifiers

PMID: 19147750
DOI: 10.1158/1078-0432.CCR-08-1757

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-19147750-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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