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Article

Functional analysis of epidermal growth factor receptor (EGFR) mutations and potential implications for EGFR targeted therapy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2009

Kancha Rama Krishna, von Bubnoff Nikolas, Peschel Christian, Duyster Justus

Abstract excerpt

PURPOSE: Epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) might be predictive for clinical response to EGFR inhibitor treatment. However, retrospective analyses of EGFR mutations in clinical trials have shown inconclusive results and the effect of EGFR sequencing in NSCLC is still controversial. Because the vast majority of EGFR mutations described have not been functionally...

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Identifiers

PMID: 19147750
DOI: 10.1158/1078-0432.CCR-08-1757

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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