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Article

Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model.

The Journal of clinical investigation - 1 Jul 2016

Kwon Oh-Joon, Zhang Li, Wang Jianghua, Su Qingtai, Feng Qin, Zhang Xiang H F, Mani Sendurai A, Paulter Robia, Creighton Chad J, Ittmann Michael M, Xin Li

Abstract excerpt

Although Notch signaling is deregulated in prostate cancer, the role of this pathway in disease development and progression is not fully understood. Here, we analyzed 2 human prostate cancer data sets and found that higher Notch signaling correlates with increased metastatic potential and worse disease survival rates. We used the Pten-null mouse prostate cancer model to investigate the function of Notch signaling...

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Share to Epithelial-Mesenchymal Transition
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 27294523
DOI: 10.1172/JCI84637
PMCID: PMC4922719

Genes

FOXC2
RBPJ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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