Article
Aberrant regulation of MyoD1 contributes to the partially defective myogenic phenotype of BC3H1 cells.
The Journal of cell biology - 1 Apr 1990
Brennan T J, Edmondson D G, Olson E N
Abstract excerpt
Two skeletal muscle-specific regulatory factors, myogenin and MyoD1, share extensive homology within a myc similarity region and have each been shown to activate the morphologic and molecular events associated with myogenesis after transfection into nonmyogenic cells. The BC3H1 muscle cell line expresses myogenin and other muscle-specific genes, but does not express MyoD1 during differentiation. BC3H1 cells also...
Topics
- Animals
- Azacitidine
- Blotting, Northern
- Cell Line
- Gene Expression Regulation
- Genes
- Mice
- Muscle Proteins
- Muscles
- MyoD Protein
- Myogenin
- Nuclear Proteins