Article
Overexpression of myotonic dystrophy kinase in BC3H1 cells induces the skeletal muscle phenotype.
The Journal of biological chemistry - 5 Jan 1996
Bush E W, Taft C S, Meixell G E, Perryman M B
Abstract excerpt
Myotonic muscular dystrophy is an autosomal dominant defect that produces muscle wasting, myotonia, and cardiac conduction abnormalities. The myotonic dystrophy locus codes for a putative serine-threonine protein kinase of unknown function. We report that overexpression of human myotonic dystroph...
Topics
- Base Sequence
- Cell Line
- Creatine Kinase
- DNA, Complementary
- Gene Expression Regulation, Enzymologic
- Humans
- Isoenzymes
- Molecular Sequence Data
- Muscle, Skeletal
- Myotonic Dystrophy
- Phenotype
- Protein Serine-Threonine Kinases