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Article

Overexpression of myotonic dystrophy kinase in BC3H1 cells induces the skeletal muscle phenotype.

The Journal of biological chemistry - 5 Jan 1996

Bush E W, Taft C S, Meixell G E, Perryman M B

Abstract excerpt

Myotonic muscular dystrophy is an autosomal dominant defect that produces muscle wasting, myotonia, and cardiac conduction abnormalities. The myotonic dystrophy locus codes for a putative serine-threonine protein kinase of unknown function. We report that overexpression of human myotonic dystrophy protein kinase induces the expression of skeletal muscle-specific genes in undifferentiated BC3H1 muscle cells. BC3H1...

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Source

Identifiers

PMID: 8550617
DOI: 10.1074/jbc.271.1.548

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Overexpression of myotonic dystrophy kinase in BC3H1 cells induces the skeletal muscle phenotype.PMID 8550617Read ↗

Decreased levels of myotonic dystrophy protein kinase (DMPK) and delayed differentiation in human myotonic dystrophy myoblastsSemantic proximity Read ↗

Identification, Tissue-specific Expression, and Subcellular Localization of the 80- and 71-kDa Forms of Myotonic Dystrophy Kinase ProteinSemantic proximity Read ↗

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Activation of the MEF2 transcription factor in skeletal muscles from myotonic mice.Semantic proximity Read ↗

Aberrant regulation of MyoD1 contributes to the partially defective myogenic phenotype of BC3H1 cells.Semantic proximity Read ↗

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Mos activates myogenic differentiation by promoting heterodimerization of MyoD and E12 proteins.Semantic proximity Read ↗

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