Article
RecB-dependent mutator phenotype in Neisseria meningitidis strains naturally defective in mismatch repair.
DNA repair - 9 Dec 2006
Colicchio Roberta, Pagliarulo Caterina, Lamberti Florentia, Vigliotta Giovanni, Bruni Carmelo Bruno, Alifano Pietro, Salvatore Paola
Abstract excerpt
Several invasive serogroup B meningococcal strains phylogenetically related to the lineage III (ET-24) exhibited a mutator phenotype as shown by mutagenicity assay using rifampicin-resistance as a selection marker. Hypermutation was associated to the presence of defective mutL alleles that were genetically characterized. Interestingly, the mutator phenotype was suppressed when a non-functional recB(ET-37) allele,...
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