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Article

Alteration of the pH-dependent ion selectivity of the colicin E1 channel by site-directed mutagenesis.

The Journal of biological chemistry - 25 Apr 1990

Jakes K S, Abrams C K, Finkelstein A, Slatin S L

Abstract excerpt

Colicin E1 is a soluble, bacteriocidal protein that forms voltage-gated channels in planar lipid bilayers. The channel-forming region of the 522-amino acid protein is near the COOH terminus, and contains a 35-amino acid hydrophobic segment which is presumed to be important in interacting with the membrane. We have used site-directed mutagenesis in the region immediately upstream from the hydrophobic segment to...

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PMID: 1691183

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