Article
Differential induction of tumor necrosis factor by bacteria expressing rough and smooth lipopolysaccharide phenotypes.
Infection and immunity - 1 Dec 1991
Kelly N M, Young L, Cross A S
Abstract excerpt
The lipid A portion of the lipopolysaccharide (LPS) molecule of gram-negative bacteria has the ability to turn on the production of tumor necrosis factor (TNF) in macrophage cells. The question addressed in this paper was whether the presence of the polysaccharide moiety on the LPS molecule had any bearing on this ability. The question was asked (i) by using isolated LPS from a series of Salmonella mutants having...
Topics
- Bacteria
- Carbohydrate Sequence
- Endotoxins
- Lipid A
- Lipopolysaccharides
- Molecular Sequence Data
- Phenotype
- Tumor Necrosis Factor-alpha