Article
Binding of surfactant protein A to the lipid A moiety of bacterial lipopolysaccharides.
The Biochemical journal - 15 Oct 1994
Van Iwaarden J F, Pikaar J C, Storm J, Brouwer E, Verhoef J, Oosting R S, van Golde L M, van Strijp J A
Abstract excerpt
Surfactant protein A (SP-A) enhances the phagocytosis of opsonized and non-opsonized bacteria by alveolar macrophages, but it is not known with which component of the bacterial surface it associates. We investigated the interaction of SP-A with lipopolysaccharides (LPS), which are important biolo...
Topics
- Bronchoalveolar Lavage Fluid
- Calcium
- Dose-Response Relationship, Drug
- Escherichia coli
- Flow Cytometry
- Fluorescein-5-isothiocyanate
- Humans
- Lipid A
- Lipopolysaccharides
- Microspheres
- Mutation
- Protein Binding
- Proteolipids
- Pulmonary Surfactant-Associated Protein A
- Pulmonary Surfactant-Associated Proteins