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Article

Measurement methods and accuracy in copy number variation: failure to replicate associations of beta-defensin copy number with Crohn's disease.

Human molecular genetics - 15 Dec 2010

Aldhous Marian C, Abu Bakar Suhaili, Prescott Natalie J, Palla Raquel, Soo Kimberley, Mansfield John C, Mathew Christopher G, Satsangi Jack, Armour John A L

Abstract excerpt

The copy number variation in beta-defensin genes on human chromosome 8 has been proposed to underlie susceptibility to inflammatory disorders, but presents considerable challenges for accurate typing on the scale required for adequately powered case-control studies. In this work, we have used acc...

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Identifiers

PMID: 20858604
DOI: 10.1093/hmg/ddq411
PMCID: PMC2989891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20858604-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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