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Article

Genome-Wide Copy Number Variation Scan Identifies Complement Component C4 as Novel Susceptibility Gene for Crohn's Disease.

Inflammatory bowel diseases - 1 Mar 2016

Cleynen Isabelle, Konings Peter, Robberecht Caroline, Laukens Debby, Amininejad Leila, Théâtre Emilie, Machiels Kathleen, Arijs Ingrid, Rutgeerts Paul, Louis Edouard, Franchimont Denis, De Vos Martine, Van Steen Kristel, Georges Michel, Moreau Yves, Vermeesch Joris, Vermeire Séverine

Abstract excerpt

BACKGROUND: The genetic component of Crohn's disease (CD) is well known, with 140 susceptibility loci identified so far. In addition to single nucleotide polymorphisms typically studied in genome-wide scans, copy number variation is responsible for a large proportion of human genetic variation. METHODS: We performed a genome-wide search for copy number variants associated with CD using array comparative genomic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26595553
DOI: 10.1097/MIB.0000000000000623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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